Casa La Quercia is perfect as start point for daily trips across the wonder of Tuscany, due to its geographical position.
Firenze is reacheable by train (35 min, one train per hour from San Giovanni Valdarno) or by car (autostrada A1, 30min); Arezzo also is approachable by train (25min) or by car (autostrada A1 to Rome, 25 min).
Siena is 45min away by car, across the beautiful Chianti landscapes and vineyards; S.Gimignano and Volterra are reachable in less than 90min; Pisa also is approachable in about 90min by car (all of these are also reachable by train passing through Firenze railway station).
The Tirreno seaside is about 2h away by car.